JASCO developed the high-throughput CD measurement system combining an autosampler, syringe pump, and flow cell unit for use with the J-1500/J-1700. This system can accommodate two 96-well plates (up to 192 samples) and maintain a constant temperature prior to measurement. The system allows automated scanning measurements at predetermined parameters and/or temperature ramping measurements by using a Peltier thermostatted flow cell. In addition to CD, LD, and absorbance data, fluorescence can be simultaneously measured as an option. Software control allows samples to be recovered after measurement for further analysis. The analysis program allows batch processing of data including determination of Tm and secondary structure analysis.

The J-1000 Series Circular Dichroism spectrophotometers are specifically designed for high sensitivity measurements in the near- and far-UV regions, for scientists that need confidence in the data from characterization studies of biomolecule structure, function, and stability under a wide variety of experimental conditions.
Unlike some detectors which only provide good signal-to-noise for low absorbing materials, the J-1000 Series circular dichroism spectrophotometers use high dynamic range detectors to obtain high-quality spectra of samples with excellent signal-to-noise, especially for highly absorbing materials found in the far-UV.

The J-1100 Circular Dichroism spectrophotometer is a compact, general-purpose space-saving design. This simple yet powerful instrument is perfect for users looking to obtain more routine CD measurements in both industry and academia.
The J-1100 uses simple optimized parameters so that a wide range of users with different levels of CD knowledge can get right down to work and successfully obtain high quality data. The wavelength range from 180 to 600 nm is suitable for obtaining secondary and tertiary structure measurements in the near- and far- UV. The intuitive Spectra Manager™ Suite of spectroscopy software provides the user with sample measurement, independent from the data processing and analysis. This allows users to obtain new measurements while simultaneously analyzing previously acquired data for increased productivity.

The J-1500 allows for the maximum flexibility to upgrade your CD system with different measurement techniques. While the standard measurement modes are CD, LD, and absorbance, up to four simultaneous modes can be measured when combined with a wide range of sampling accessories.
These accessories can measure a variety of samples, from liquids to films to solid-states. Temperature control systems can be coupled with multi-position cells to run thermal melts, providing researchers with CD and thermodynamic data sets for conformational and folding studies. Automated high-throughput CD can obtain measurements on up to 192 samples without user intervention, saving both time and money. Kinetic and protein dynamics studies can be performed with our dedicated stopped-flow systems that can measure both CD and fluorescence.
The wavelength range has also been significantly extended, allowing measurements to be obtained in both the vacuum-UV and NIR spectral regions using the standard PMT detector (163 – 950 nm) and an optional InGaAs detector (up to 1600 nm). Additional features now allow researchers to optimize their parameter specifications in order to obtain data with the highest resolution and S/N performance for a specific application set.

The J-1700 was specifically designed for more demanding near-infrared CD applications. In addition to the enhanced far-UV capabilities, researchers probing the chiral activity of molecules in the NIR spectral region now have the ability to obtain data at wavelengths up to 2500 nm. The InGaAs detector has a wavelength range from 900-2500 nm, while the PMT ranges from 163-960 nm. The automatic detector interchange allows researchers to obtain both far-UV and NIR measurements without having to manually switch detectors. The addition of a grating monochromator to the double-prism monochromator setup provides low stray light and high light intensity, generating CD signals with high S/N performance throughout a large spectral range.

The FVS-6000 vibrational circular dichroism spectrometer measures both IR absorption and VCD, and provides accurate and highly sensitive measurement in the fingerprint region. It also has several unique features such as a wide measurement range option of 4,000-750 cm-1. with a choice of detectors. Since the VCD signals in the infrared region are typically one or more orders of magnitude lower than ECD signals in the UV-Visible region, high sensitivity and stability are especially important for a VCD spectrometer.